Identifying a Murine Xenograft Model Relevant to Light-Chain Specific Approaches to Human Ig Light-Chain Diseases

Organ-specific (localized) synthesis of Ig light chain amyloid.

Ig amyloidosis is usually a systemic disease with multisystem involvement. However, in a significant number of cases amyloid deposition is limited to one specific organ. It has not been determined if the Ig light chain (LC) amyloid precursor protein in localized amyloidosis is synthesized by circulating plasma cells with targeting of the amyloid fibril-forming process to one specific organ, or ...

Targeting human B-cell malignancies through Ig light chain-specific cytotoxic T lymphocytes.

PURPOSE The variable regions of Ig (idiotype, Id) expressed by malignant B cells can be used as tumor-specific antigens that induce humoral and cellular immunity. However, epitopes derived from Id that stimulate human CD8(+) T-cell immunity are incompletely characterized. EXPERIMENTAL DESIGN The clonal Ig V(L) of human myeloma cell line U266 and five primary B-cell tumors were sequenced, and ...

Cancer Therapy: Preclinical Targeting Human B-cell Malignancies through Ig Light Chain–Specific Cytotoxic T Lymphocytes

Purpose: The variable regions of Ig (idiotype, Id) expressed by malignant B cells can be used as tumorspecific antigens that induce humoral and cellular immunity. However, epitopes derived from Id that stimulate human CD8þ T-cell immunity are incompletely characterized. Experimental Design: The clonal Ig VL of human myeloma cell line U266 and five primary B-cell tumors were sequenced, and pepti...

A Guide To AL (Light Chain) Amyloidosis

Immunoglobulin Free Light Chain Dimers in Human Diseases

Immunoglobulin free light chain (FLC) kappa (κ) and lambda (λ) isotypes exist mainly in monomeric and dimeric forms. Under pathological conditions, the level of FLCs as well as the structure of monomeric and dimeric FLCs and their dimerization properties might be significantly altered. The abnormally high fractions of dimeric FLCs were demonstrated in the serum of patients with multiple myeloma...